In THE BIG SICK, Kumail (Kumail Nanjiani, who co-wrote the film based on his own life) is a stand-up comic/Uber driver living in Chicago. He’s pretty comfortable in his routines — which include living in fraternity-like squalor, joking around with his fellow aspiring comedians, and humoring his mother, Sharmeen (Zenobia Shroff), at weekly family dinners, as she keeps trying to set him up with marriageable Pakistani girls. Then he falls for the decidedly non-Pakistani Emily (Zoe Kazan), a grad student who swears she doesn’t want a relationship. But she keeps going out with Kumail anyway … at least until he refuses to commit to their relationship because of what his traditional family might think. Kumail’s post-breakup blues are shattered when Emily suddenly ends up gravely ill in the hospital. Even after her parents, Beth and Terry (Holly Hunter and Ray Romano), arrive on the scene, Kumail can’t bring himself to leave Emily’s side. As he builds a tentative relationship with Beth and Terry, he starts to understand that he might need to make some changes.